结肠癌（Coloncarcinoma），也被称为大肠癌，恶性肿瘤之一，严重危害着人体健康。结肠癌归根结底是体内外环境综合因素影响产生的疾病，多个基因以多个步骤的协同累积作用参与其发生发展。一般来说，导致结肠癌发生的基因的改变主要包括原癌基因的活化和抑癌基因的失活等。研究表明TOB/BTG抗增殖家族有成员在多种癌症中具有抗增殖活性，在多种癌症中表达缺失，而Tob1基因（TransducerofERBB2）就是其中之一。然而我们的前期实验观察到Tob1可促进肠癌细胞增殖；在肠癌模型小鼠APCmin/+肠息肉中表达升高且APCmin/+小鼠与Tob1敲除鼠杂交后息肉恶性度降低；吴殿超等人研究了Tob...Colorectal cancer, which is one of the most common gastrointestinal malignancies, is a serious threat to human health. They are diseases that are considered to be resulted from multitude factors, including inherit, environment, autoimmune and so forth. The occurrence mechanism of colorectal cancer depends on alteration of multi-factors, multi-stages and multi-genes, involving a wide variety of onc...学位：理学硕士院系专业：生命科学学院_细胞生物学学号：2162011115232
