戊型肝炎病毒（HepatitisEvirus，HEV）是一种无包膜的RNA病毒，主要可引起急性戊型肝炎（HepatitisE，HE），会造成消化道相关的食欲不振、恶心、呕吐等症状，严重的患者甚至会发生肝衰竭乃至死亡，尤其在育龄期妇女、慢性肝病患者、老年人和婴幼儿中有着较高的病死率，是一种严重威胁人类健康的病原体，引起了众多研究者的关注。 由于缺乏有效的HEV细胞培养模型，对HEV的病毒颗粒组装、感染机制研究和疫苗开发主要是通过各种外源表达系统进行的。HEVORF2aa112-606编码的蛋白（p495）可在昆虫细胞中体内组装成等二十面体对称的病毒样颗粒（VirusLikeParticle，V...Hepatitis E virus (HEV) is a non-enveloped RNA virus and can cause an acute viral hepatitis with the symptoms of inappetence, nausea and vomit. It also can cause liver failure and is responsible for unusually high rates of mortality in pregnant women, patients with chronic liver disease, the aged and infants. HE has been paid more attention as it is a pathogen which is hazardous to health. Since ...学位：理学硕士院系专业：生命科学学院生物学系_微生物学学号：2162010115238
