EB病毒以潜伏感染形式寄存在EB病毒相关肿瘤细胞中，NF-kB起着关键性作用。抑制NF-kB活性能够诱导EB病毒进入溶菌循环，并对肿瘤细胞产生溶菌毒性。有研究表明，阐明小白菊内酯（parthenolide，PN）具有抑制NF-kB的作用。本课题旨在探讨PN对EB病毒阳性伯基特淋巴瘤的抑制作用，以及对肿瘤细胞中EB病毒溶菌循环的诱导作用和溶菌毒性，并对其机制作初步探讨，进一步研究PN以及联合抗病毒药物治疗EB病毒阳性伯基特淋巴瘤的可行性和临床应用价值。Epstein-Barr (EBV) infection in tumor cells is generally restricted to the latent form of viral infection. The switch from latent to lytic infection may induce tumor cells death. An important nuclear factor, nuclear factor (NF)-kB, is thought to play an essential role in EBV lytic infection; Burkitt lymphoma (BL) has been reported to be strongly associated with Epstein-Barr virus (EBV) infection. ...学位：医学硕士院系专业：医学院临床医学系_内科学学号：2452009115293
