肺癌是目前发病率和死亡率居全球首位的恶性肿瘤，是严重危害人类健康的恶性疾病。相对于乳腺癌、前列腺癌等其他主要类型的恶性肿瘤，至今仍缺乏对各类肺癌发生分子机制及信号通路的认识。Men1基因是多内分泌腺瘤病1型（MEN1）发生的关键抑癌基因，编码一个含610个氨基酸残基的核蛋白质menin。Men1基因与多种人类疾病如多MEN1、垂体瘤、甲状腺肿瘤、胰岛素瘤、肾上腺肿瘤等内分泌肿瘤的发生密切相关，随着研究的深入，发现Men1在白血病、糖尿病等疾病的发生中同样起着重要的作用。但是Men1是否参与其它非内分泌肿瘤如肺癌发生知之甚少。有报道，小鼠Men1LOH可诱发散在型肺类癌；遗传学研究表明，Men1...Lung cancer is the leading cause of cancer-related deaths in the world, which is still lack of molecular mechanisms. Men1, a critical oncogene of multiple endocrine neoplasia type 1(MEN1), encodes a novel protein menin. Men1 is associated with lots of human disease such as MEN1, pituitary tumors, insulinoma and other endocrine tumors. It has been reported that Men1 also plays an important role in ...学位：医学硕士院系专业：医学院临床医学系_肿瘤学学号：2452007115255
