目的：探讨IL-19及其相关因子在大鼠实验性自身免疫性心肌炎(EAM)急慢性期各时程的表达特征及作用。 方法：将提纯精制后的猪心室肌球蛋白与相等体积含结核杆菌H37Ra株的完全弗氏免疫佐剂充分混合，于Lewis大鼠双后足皮下注射制作大鼠EAM模型；以注射生理盐水为对照组，HE和Masson染色评估EAM急慢性期（3w、3m、6m）各时程心肌损伤程度；应用实时荧光定量RT-PCR检测IL-19及其相关因子（IL-20、IL-20R1和IL-20R2）在EAM大鼠各脏器（心、肝、脾、肾）的mRNA表达及在心肌炎急慢性期各时程的mRNA表达；应用ELISA法检测心脏组织匀浆IL-19、IL-20蛋...Objective:To explore the time course and role of IL-19 and related factors（IL-20,IL-20R1/R2） in experimental autoimmune myocarditis(EAM) rat. Methods: Antigen was prepared with an emulsion of porcine cardiac myosin in complete Freund's adjuvant, plus Mycobecterium tuberculosis H37-Ra strain. EAM model was made by hypodermic injection of the myosin in hind legs of Lewis rats. In control group, ...学位：医学硕士院系专业：医学院临床医学系_内科学学号：2452009115294
