Axin是一种抑癌基因，在胚胎发育过程中控制体轴的形成。Axin是一种多功能的构架蛋白，在许多重要的信号传导途径中扮演着重要的角色：在Wnt信号通路中，Axin作为负调控因子与APC（adenomatouspolyposiscoli），GSK-3β（glycogensynthasekinase-3β），β-catenin形成蛋白复合体下调β-catenin的水平；在JNK信号通路中，Axin与MEKK1或MEKK4相互结合，激活JNK，诱导细胞凋亡；在TGF-β信号通路中，Axin通过与Smad3调节TGF-β的转录活性；在p53信号通路中，Axin与p53，HIPK2（homeodomain...Axin is a tumor suppressor gene, which plays a critical role in controlling axis formation during embryonic development. Axin serves as a scaffold protein in at least four different signaling pathways: Wnt, JNK (c-Jun NH2 terminal MAPK), TGF-β (transforming growth factorβ) and p53 signaling pathways. In the Wnt signaling pathway, Axin negatively regulates β-catenin by forming a large multimeric pr...学位：理学博士院系专业：生命科学学院生物学系_生物化学与分子生物学学号：B20032602
