小核仁RNA宿主基因（smallnucleolarRNAhostgenes,snoRNA-HGs）编码的蛋白主要在核糖体蛋白的翻译中起重要作用。但是还有一些snoRNA-HGs不具有蛋白的编码能力，比如UHG、U17HG、U19HG等，它们的生物学功能目前尚不清楚。本文应用逆转录病毒随机插入介导基因失活的方法，以鼠纤维原细胞L929为材料，筛选在肿瘤坏死因子-a（Tumornecrosisfactor-a，TNF-a）诱导细胞死亡过程中起重要作用的基因。我们获得了一株TNF抗性细胞株（U17HGmut），逆转录病毒插入到U17HG（U17hostgene,U17HG）的第一个内含子中，实时PC...Small nucleolar RNA host genes (snoRNA-HGs) encoded proteins are involved in the ribosomal protein translation. However, there are some snoRNA-HGs to have no potentials to code proteins. Until now it is still unclear about the biological functions of these non-coding-protein snoRNA-HGs. Here, using a mutagenesis screen for genes critical in TNF-induced death in L929 cells, we have found one of tho...学位：理学博士院系专业：生命科学学院生物学系_生物化学与分子生物学学号：2005140314
