肝细胞癌（HCC）是世界上最常见的恶性肿瘤之一。在我国，其死亡率在消化系恶性肿瘤中列第3位，仅次于胃癌和食管癌，近几年在发达国家也有上升趋势。HCC的形成和发展是由多基因参与并受多因素影响的复杂过程。其中的根源是基因表达的异常。Pokemon(POKerythroidmyeloidontogenicfactor)，属于POK蛋白家族，也被称作LRF，OCZF和FBI-1。作为一种转录抑制因子，Pokemon在细胞分化和肿瘤形成中发挥着关键作用。研究表明，Pokemon在人类非小细胞肺癌、恶性神经胶质瘤中过表达，在肝细胞癌(HCC)中也有表达。然而，很少有研究探讨Pokemon在肝细胞癌中的作用...Pokemon (POK erythroid myeloid ontogenic factor), which belongs to the POK protein family, is also called LRF, OCZF and FBI-1. As a transcriptional repressor, Pokemon has a critical function in cellular differentiation and oncogenesis. Pokemon is overexpressed in non-small cell lung carcinoma, malignant gliomas, and also observed expressed in hepatocellular carcinomas (HCC). Nevertheless, few stud...学位：医学硕士院系专业：医学院临床医学系_内科学学号：2452009115293
