Beta-arrestin包括Beta-arrestin1和Beta-arrestin2两种蛋白，它们在体内广泛表达，可以调节G蛋白耦联受体（Gproteincoupledreceptor，GPCR）的脱敏和内吞，是多种信号通路中的多功能调节因子。TFF3是三叶因子家族（Trefoilfactors-TFFs）成员之一，TFFs是主要由胃肠道黏液细胞分泌的可溶性小分子多肽，它们在慢性炎症、黏膜保护修复、细胞凋亡、组织化生及肿瘤的发生发展等方面具有重要的生物学功能。本实验首次在胃癌细胞BGC-823细胞系中探讨研究两者对肿瘤细胞的共同影响作用。 我们首先构建Beta-arrestin1及TFF...Beta-arrestin1 consists of Beta-arrestin1 and Beta-arrestin2. They are ubiquitously expressed and not only modulate the desensitization and trafficking of G protein-coupled receptors (GPCRs) but also serve as multi-functional adaptors which contribute to the regulation of multiple signaling molecules. TFF3 is one of the The trefoil factor (TFF) family which are secreted chiefly from the mucus-secr...学位：医学硕士院系专业：医学院临床医学系_内科学学号：2452008115343
