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Isolation and Structure Elucidation of Bioactive Secondary Metabolites from Four Actinomycetes

Abstract

天然产物在新药物的探索和研发中发挥着重大作用,微生物次级代谢产物又是天然产物的主要组成部分之一,因而对微生物次级代谢产物进行研究具有重要的意义。 本论文对4株AHBA合酶基因阳性菌株(2株植物根际链霉菌、1株植物内生链霉菌和1株海洋小单孢菌)的次级代谢产物进行了研究,共分离鉴定了37个化合物的结构,其中4个为新化合物。 从来自青海的叶楸根际链霉菌Streptomycessp.XZqh-8菌株ISP3和SYP固体培养基发酵粗提物中分离鉴定了7个化合物,其中4个蒽环类化合物,为Aklavinone及其糖苷衍生物(8QM-1,8QM-5,8QM-6和8QM-7);2个吲哚酮类化合物(8Q-2和8...Natural products play an important role in the research and development of new drugs, as the same time, microbial secondary metabolites is one of the significant components of natural products. So, it has great value to do the exploration of microbial secondary metabolites. In the thesis, secondary metabolites from four actinomycetes including two rhizosphere Streptomyces, one endophytic Streptom...学位:理学硕士院系专业:生命科学学院生物学系_微生物学学号:2172009115214

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