乙型肝炎病毒（HepatitisBVirus，HBV）感染是一个全球性的公共健康问题，其慢性感染引起的病毒性肝炎是严重威胁人类健康的常见病和多发病。目前对HBV的慢性感染尚缺乏非常有效的治疗手段。临床上具有持续性疗效的方法是利用IFN-α进行系统治疗，可在40％患者体内取得抑制HBV复制的效果，但仅有5%～10％接受治疗的患者HBsAg转阴。此外，利用核酸类似物如拉米夫定(lamivudine)进行治疗可以快速降低血清HBVDNA水平并使得症状好转，但短期治疗会导致肝病迅速复发，长期治疗易形成抗性病毒变异株。近来对HBV感染的过继性免疫治疗研究日益增多，过继免疫治疗普遍采用体外抗原负载树突状细...More than 2 billion people alive today have been infected with hepatitis B virus (HBV) at some time in their life worldwide, and of these, about 350 million remain infected. Although many cases of chronic HBV infection can resolve spontaneously, some still progress to cirrhosis and hepatocellular carcinoma, which kill 1 million people every year. Thus, HBV infection had become a major public healt...学位：理学硕士院系专业：医学院药学系_微生物学学号：2452008115342
