不溶性Aβ（β-amyloid，Aβ）的沉积是阿尔茨海默症（Alzheimer’sdisease，AD）发病的中心环节，Aβ是由β分泌酶和γ分泌酶顺序切割β淀粉样蛋白前体蛋白（β-amyloidprecursorprotein，APP）产生的，而β位点APP剪切酶1（β-siteAPPcleavingenzyme1，BACE1）被认为是主要的β分泌酶，所以BACE1是Aβ形成的关键酶。BACE1与APP在细胞内的转运过程受到许多因素的调节，它们在质膜、内体/溶酶体、TGN以及早期分泌途径之间的转运和定位在很大程度上影响了Aβ的产生，近年来已经成为AD研究及治疗靶点的热点之一。 SNX12（S...The deposition of insoluble β-amyloid (Aβ) is the key event in Alzheimer’s disease (AD). Aβ is produced through sequential proteolytic cleavages of the β-amyloid precursor protein (APP) by β-secretase and γ-secretase; and β-site APP cleaving enzyme 1 (BACE1) is considered to be the major β-secretase. Hence, BACE1 has been identified as the key setecrase leading to Aβ formation. BACE1 and APP are m...学位：理学博士院系专业：药学院_化学生物学学号：3052009015359
