高危型人乳头瘤病毒(Humanpapillomavirus，HPV)的持续感染被认为是诱发女性宫颈癌的主要因素。宫颈癌在危害妇女健康的恶性肿瘤疾病中居第二位。世界范围内，宫颈癌每年大约有50万新发病例，死亡人数约20万；中国每年约有13万人罹患宫颈癌。与宫颈癌发生密切相关的高危型HPV有15个型别以上，其中，HPV16与18约占70%。目前，HPV疫苗被认为是防控包括宫颈癌在内的宫颈疾病的最有效手段，而现有的HPV疫苗多因成本与制造工艺困难等因素，仅能覆盖HPV16与18两个型别，无法满足需要。因此，有必要开发一种覆盖型别更广，保护率更高的HPV疫苗。扩大疫苗保护型别、L2疫苗、嵌合颗粒疫苗成...The persistent infection of high-risk HPV usually resulted in cervical cancer, which ranks second in the most common malignant tumors threatening women’s health. About 500,000 people are found to suffering from cervical cancer globally, with 200,000 fatal cases each year. And there is about 13 million people suffered from cervical cancer in China yearly. Among the more than 15 kinds of high-risk H...学位：理学硕士院系专业：生命科学学院生物学系_细胞生物学学号：2172009115219
