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The Study of Pathogenic Mechanism of Demodex Blepharitis

Abstract

研究背景蠕形螨(Demodex)是一种小型专性寄生螨类,是人体常见的永久性体外寄生虫。在眼部,寄居于睫毛毛囊,皮脂腺以及睑板腺内。由于其较高的人群感染率,而且一些蠕形螨感染者并不表现明显的症状,长期以来其致病性一直存有争议。越来越多的研究证实蠕形螨与慢性睑缘炎、结膜炎、睑板腺功能障碍等眼表疾病有关,但大多只是从流行病学以及临床相关性上阐释其致病性,而其确切的致病机制目前仍不清楚。 目的探讨蠕形螨在睑缘炎中对毛囊及睑板腺结构的致病作用。 方法选择临床诊断睑缘炎患者,行睫毛取材镜检,蠕形螨阳性者确诊为蠕形螨性睑缘炎。选择20例蠕形螨性睑缘炎患者,应用TUNEL法检测睫毛毛球部细胞凋亡情况,并与...Background: Demodex is an obligate permanent parasite and commonly detected in human. It inhabits in hair follicle, sebaceous gland and meibomian gland. The pathogenicity is controversial since some healthy infesters do not show any obvious symptoms. More and more studies revealed high relevance of Demodex in ocular diseases such as chronic blepharitis, conjunctivitis, and meibomian gland dysfunct...学位:医学硕士院系专业:医学院临床医学系_肿瘤学学号:2452007115254

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