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Study on the effect of chitosan on Deacetylmycoepoxydiene production

Abstract

海洋微生物生境特殊,具有独特的代谢途径。海洋微生物的次级代谢产物是新药物研究开发的重要资源。如何提高微生物的次级代谢产物的产量,是目前海洋微生物开发亟待解决的问题。近年来,使用诱导子来刺激代谢途径已经成为提高目的产物产量的主要策略之一。 本论文尝试采用诱导子来提高海洋抗肿瘤候选新药去乙酰真菌环氧乙酯(Deacetylmycoepoxydiene,缩写为DAM)的产量,并对诱导机制进行初步的探索。DAM是红树植物内生真菌A123(Phomopsissp.A123)产生的一种骨架新颖的环氧二烯类化合物。前期研究表明,DAM具有较强的细胞毒性,对Raji细胞株IC50为3.0µg/mL...Because of their special living conditions, marine microorganisms often produce various bioactive substances with novel functions and structures. However, the yields of secondary metabolites in the marine fungi are usually too low to carry out further studies on bioactivity or pharmacological properties. Looking for methods to enrich the yield of secondary metabolites is the way to overcoming the ...学位:理学硕士院系专业:生命科学学院生物学系_微生物学学号:2172008115254

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