肺癌为恶性肿瘤中较为常见的类型之一，而非小细胞肺癌又是肺癌的主要类型，约占肺癌总数80-85%。Tumornecrosisfactor(TNF)-α-inducedprotein8(TNFAIP8/TIPE)是2000年由Kumar等发现的一种和细胞凋亡密切相关的调节蛋白，包含一个死亡效应结构域(DED)，能够抑制Caspase介导的细胞凋亡。现有研究提示，TIPE在人乳腺癌中起到癌基因的作用，同时也有研究揭示TIPE与肺癌转移密切关系，但到目前为止，TIPE在肺癌发生发展中的作用及相关机制并未明晰。本课题首先以免疫组化检测人非小细胞肺癌组织和癌旁TIPE表达情况；次以CCK-8细胞增殖实验、...TIPE was originally identified in human metastatic head and neck squamous cell carcinoma (HNSCC) cell lines.Over-expression of TIPE is associated with enhanced abilities of cell survival, which was mediated by inhibiting of activities of apoptotic enzymes caspase-8 and caspase-3, indicating that TIPE might be act as an oncogene in human cancers. But, until to now, little is known about the role of...学位：理学硕士院系专业：医学院基础医学系_微生物学学号：2452009115300
