Study on the fibrosis mechanism of communicating hydrocephalus induced following intra-ventricular kaolin injection in adult rats and the effect of anti-fibrosis therapy with the pHGF
目的：研究交通性脑积水大鼠模型纤维化发生机制以及pHGF抗脑积水纤维化作用。 方法：雄性SD大鼠（250±10g），随机分成4组：生理盐水对照组，脑积水组，阴性干预对照组（生理盐水干预）和pHGF干预组，每组15只。脑积水组采用侧脑室注射3%高岭土混悬液制备交通性脑积水模型；对照组给予生理盐水注射；pHGF干预组：3%高岭土混悬注射后同时给予pHGF微渗透泵（pHGF浓度40mg/ml）干预；阴性干预对照组：3%高岭土混悬注射后给予生理盐水微渗透泵。10天后对4组分别进行Morris水迷宫实验，第15天行MRI检测，然后收集脑脊液，处死动物，收集脑组织标本，行HE、免疫组化、Elisa和RT...Purpose:This study attempted to investigate the mechanism of the fibrosis of communicating hydrocephalus induced following intra-ventricular kaolin injection in adult rats and the effect of anti-fibrosis therapy with the pHGF. Methods: Adult male Sprague-Dawley rats (250 ±10g) were randomly divided into 4 groups: control group (n=15), hydrocephalic group (n=15), saline treatment group (n=15) and...学位：医学硕士院系专业：医学院临床医学系_外科学学号：2452009115299
