作为持久性有机污染物之一的多氯联苯(PolychlorinatedBiphenyls，PCBs)引起的环境问题已受到极大关注。尽管有研究表明PCBs与糖尿病和胰腺癌有关，但关于PCBs对胰腺毒性的机制研究仍然很不清楚。本研究以C57BL/6品系青春期雄性小鼠为研究对象，研究环境水平的PCBs对胰腺的毒性影响。采用浓度分别为0.5、5、50和500μg/kg的Aroclor1254，通过灌胃法对小鼠进行染毒，每三天灌胃一次，暴露持续50天。主要研究结果如下： 1、Aroclor1254暴露小鼠50天后，小鼠体重没有出现显著变化，但胰腺重量呈现剂量依赖性下降。组织学观察胰腺外分泌部的腺泡细胞体积...As one of the persistent organic pollutants, Polychlorinated biphenyls (PCBs) has raised much concern. It has been reported that PCBs associated with Diabetes and pancreatic cancer. However, the effects and mechanisms of PCBs on the islets and exocrine pancreas are still unclear. The aim of this study was to examine the toxic effects of PCBs on the pancreas in male mice and to look into the toxico...学位：理学硕士院系专业：生命科学学院生物学系_动物学学号：2162007115199
