Edg（endothelialdifferentiationgene）受体家族属于G蛋白偶联受体亚家族，介导S1P（磷脂酸鞘氨醇，sphingosine-1-phosphate）和LPA（溶血磷脂酸，sysophosphatidicacid）信号，参与细胞增殖、迁移、分化、细胞骨架重组和细胞凋亡等细胞活动调节，在血管及神经发育、生殖、移植、免疫、损伤修复、肿瘤和自身免疫性疾病等生理病理过程中发挥作用。目前在人和小鼠中已发现八个Edg受体家族成员，根据它们结合的配体分子分为S1P亚家族（S1p1/Edg1、S1p2/Edg5/H218/AGR16、S1p3/Edg3、S1p4/Edg6和S1p5...Edg (Endothelial differentiation gene) family receptors belong to the G protein-coupled receptors(GPCR) subfamily. Up to now, eight members of this family have been found in human and in mice, and they can be classified into two subfamilies based on their ligand specificity: the S1P receptor subfamily , including S1p1 (Edg1), S1p2 (Edg5/H218/AGR16), S1p3 (Edg3), S1p4 (Edg6) and S1p5（Edg8）; and the...学位：理学硕士院系专业：生命科学学院生物学系_细胞生物学学号：2172006115219
