选择性栓塞肿瘤组织血管从而诱发肿瘤组织的缺血性坏死是一种很有前景的抗肿瘤策略。利用导向载体构建载体-tTF融合蛋白，将截断的组织因子tTF选择性靶向于肿瘤组织血管膜表面，可以诱发肿瘤组织血管栓塞，阻断肿瘤营养物质和氧气的供给，引发肿瘤缺血性坏死，发挥抗肿瘤作用。Neuropilin-1(NRP1)是相对分子质量(Mr)为120–130kDa的跨膜糖蛋白，被发现在肿瘤内皮细胞和肿瘤细胞上都有高表达。Neuropilin-1是血管内皮生长因子165(VEGF165)的非酪氨酸激酶受体，它的过表达与肿瘤血管新生和生长相关，因此NRP-1可能成为抗肿瘤治疗的靶点。HaiyanJia等设计出的短肽EG3...Selective thrombosis in tumor vessels and induction of subsequent tumor infarction is a promising anti-tumor strategy. tTF(truncated tissue factor) is only the extracellular domain of tissue factor. When tTF is targeted to the tumor vasculature by the ligand of tTF fusion protein and contacts with the cell membrane closely, it could induce thrombosis in tumor vasculature and cut off nutrition and ...学位：理学硕士院系专业：生命科学学院生物学系_生物化学与分子生物学学号：2172006115221
