阿尔茨海默症(Alzheimer’sdisease，AD)是一种渐进性神经退行性疾病。其发病机制至今仍不清楚。在患者脑部出现两个明显的病理组织学特征：即细胞内神经原纤维缠结(neurofibrillarytangle，NFT)和细胞外形成淀粉样斑(senileplaque，SP)。淀粉样斑主要由淀粉样蛋白(Aβ)组成。目前绝大多数观点认为AD的发病主要是由于大脑中Aβ的过度产生和堆积所造成。Aβ是由β分泌酶和γ分泌酶顺序切割APP产生的，γ分泌酶是一种大分子复合物，由presenilin(包括presenilin1andpresenilin2)、nicastrin，APH-1和PEN-2。Pr...Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. There are two important pathological features in the brain of AD patients: neurofibrillary tangle (NFT) and senile plaque(SP). Senile plaques are composed of β-amyloid(Aβ)peptides, whose excessive generation and aggregation is regarded as a primary cause of AD pathogenesis. Aβ is derived from its precursor protein APP through se...学位：理学硕士院系专业：生命科学学院生物学系_生物化学与分子生物学学号：2172006115222
