盐酸曲马多(Tramadolhydrochloride,TH)作为一种非麻醉性中枢镇痛药，已经成为世界范围内最广泛使用的处方药。关于曲马多在脊椎动物中的积极作用的报导曾经一直占据主导地位，包括缓解中度至重度疼痛、抗抑郁、抗炎和免疫刺激作用、排尿控制、降低糖尿病症体内的血糖浓度等。然而，近年来曲马多滥用中毒、不良反应和依赖性的市场监测报告和临床案例却日益增多，而滥用相关的神经毒性、功能障碍和依赖性潜力的细胞和分子水平机理的研究报道却极少。因而，迫切需要从分子和细胞水平对曲马多滥用可能造成的依赖性潜力和神经毒性等进行微观分析。本论文选用斑马鱼(Daniorerio)为研究对象，从行为学角度观察和统...Tramadol hydrochloride (TH), an atypical centrally acting opioid analgesic, has become the most prescribed drug worldwide. Previous reports predominantly have focused on the numerous positive response of TH in vertebrates, including analgesia for moderate to severe pain; antidepressant, anti-inflammatory, and immunostimulatory effects, micturition control; an ability to lower glucose in diabetics ...学位：理学博士院系专业：生命科学学院生物学系_生物化学与分子生物学学号：2162006015333
