在血管系统发育的过程中,出芽生长是新血管形成的关键过程之一。出芽生长是一个动态过程,血管内皮生长因子(Vascularendothelialgrowthfactor,VEGF)的刺激为出芽生长所必需,促血管生成素(Angipoitins)及其受体Ties等信号系统也控制着这一过程的发生。但对于这个重要的生物过程具体分子调节机制,尚有很多不明之处。在淋巴管发育中,这方面的机制则知之更少。Neuropilin2(Nrp2)是一个跨膜的受体蛋白,是Semaphrin3家族和VEGF家族的某些成员,包括VEGF-C的共同受体。本论文研究中,我们证明了Nrp2在淋巴管出芽生长中起着很重要的作用。用Nrp...In the course of vascular development, sprouting is one of the key processes to drive new vessel formation. Vascular sprouting is a dynamic process. Stimulation of vascular engothelial growth fator (VEGF) is required in this process, and other signalling pathways such as Agiopoitins / Ties also involved in the controlling of the process. However, the detail molecular mechanisms that regulate this...学位:理学博士院系专业:生命科学学院生物学系_生物化学与分子生物学学号:2162006015332