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Genome-Wide Detection of Tissue-Specific Genes & Database Construction

Abstract

组织特异表达基因(Tissue-SpecificGene)是指在某一种或少数几种组织或细胞中特异表达的基因。研究组织特异表达基因有助于我们更好地理解组织和基因的关系,有助于我们找到疾病的发病原因,同时有助于我们发现新的组织特异的药物靶点。 目前已出现不少研究组织特异表达基因的方法,包括传统的实验方法、高通量实验方法以及生物信息学方法。在使用生物信息学方法研究组织特异表达基因领域,虽然已经有了组织特异表达基因的数据库,例如GEO,ArrayExpress,TiGER,BODYMAP,BioGPS和TissueDistributionDBs等数据库,这些数据库也有部分采用数学算法用于发现组织特异...The tissue-specific genes are a group of genes whose function and expression are preferred in one or several tissues/cell types. Identification of these genes helps better understanding of tissue-gene relationship, disease etiology and discovery of novel tissue-specific drug targets. Nowadays, besides traditional experiment methods, a few Bioinformatics methods were developed to facilitate detec...学位:理学硕士院系专业:生命科学学院生物学系_微生物学学号:2162007115199

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