内皮损伤和炎症是动脉粥样硬化的主要特点。修复内皮细胞功能已成为防治动脉粥样硬化的靶点。我们在前期研究中发现：诱导大鼠的内皮祖细胞（endothelialprogenitorcells，EPCs)炎症时，经下调EPC中ABIN-2蛋白的表达，Ang-1对炎症反应的抑制作用消失。ABIN-2蛋白是NF-kB内源性抑制物，能够抑制NF-kB的活性，而在调节炎症反应的信号通路中，NF-kB信号途径被认为是经典的一条途径。那么Ang-1调节炎症反应是否通过抑制NF-kB发挥作用？为此，我们使用NF-kB特异性抑制剂抑制其活性，通过观察NF-kB失活后Ang-1对炎症反应的作用，论证NF-kB信号传导通路...Endothelial dysfunction and inflammation are the main features of atherosclerosis. Repairing of endothelial function is as a therapeutic target for atherosclerosis. In the preliminary study of this subject, we found that in the inflammation of endothelial progenitor cells,after reduced the expression of ABIN-2 protein , Ang-1 inhibition of inflammatory responses disappeared . ABIN -2 protein is e...学位：医学硕士院系专业：医学院临床医学系_内科学学号：2452008115343
