口蹄疫(Foot-and-mouthdisease，FMD)是由口蹄疫病毒(Foot-and-mouthdiseasevirus，FMDV)引起的烈性传染病，其爆发、流行会带来巨大的经济损失。目前国际上常用的口蹄疫疫苗为灭活疫苗，但是如果灭活不完全可能会导致病毒传染。因此需要开发一种安全有效的新型口蹄疫疫苗。FMDV的VP1蛋白含有多个重要的抗原表位，能有效的诱发FMDV特异的免疫反应，因此针对VP1设计的疫苗是当前FMDV疫苗研究的热点。粘膜免疫系统是抵抗病原微生物入侵的重要屏障。FMDV作为一种传染性疾病，粘膜IgA对动物抵抗病毒的入侵可能也具有不可忽视的作用。经由粘膜途径免疫的FMDV疫...Foot-and-mouth disease virus (FMDV) is the serious causative agent of foot and mouth disease which affects meat-and milk-producing of livestock. Although they are effective for the prevention and control of the disease, inactivated virus which is utilized as current vaccines have considerable potential risk. So it is necessary to develop alternative vaccines. Production of complete VP1 or critical...学位：理学硕士院系专业：生命科学学院生物学系_细胞生物学学号：20042615
