肿瘤耐药性（CancerResistancetoDrug），系指肿瘤细胞对于药物作用的耐受性，耐药性一旦产生，药物的作用就明显下降，除外科手术外，内分泌治疗是乳腺癌治疗的主要手段,以他莫昔芬(Tamoxifen)和托瑞米芬(Toremifene)为代表的选择性雌激素受体调节剂(SERM)是最具代表性的内分泌治疗药物。尽管他莫昔芬和托瑞米芬在大多数受体阳性患者中初治有效且耐受良好,但仍有约40~50%的雌激素受体(ER)阳性患者无效,甚至有部分初治敏感者在用药过程中发生耐药而导致疾病进展和死亡。乳腺癌中酪氨酸磷酸酶Shp2(TheSrchomologyphosphotyrosylphosphat...Cancer Resistancet Drug refers to tumor cells to drug tolerability,once produced, the drug significantly decreased role of therapy.Other than surgery, the endocrine treatment of breast cancer treatment is the primary means to tamoxifen and toremifene as the representative of the selective estrogen receptor modulator (SERM), is the most representative Endocrine therapy. Although tamoxifen and torem...学位：理学硕士院系专业：生物医学研究院_化学生物学学号：3052008115269
