海洋放线菌分布广,种类多,可产生许多结构新颖、功能独特及毒副作用较低的次级代谢产物,是寻找新药或先导化合物的重要资源。本论文对13株分离自深海底泥和海洋动植物体的海洋放线菌的抗菌、抗乙酰胆碱酯酶和抗肿瘤等活性进行了分析,并对其中一株具有较强体外抗肿瘤活性菌株的次级代谢产物进行了较系统的研究,旨在发掘具有潜在应用前景的活性化合物,为开发新的微生物药物奠定基础。 采用改进的Ellman法,微量液体稀释法和MTT法,分别对13株海洋放线菌的3种培养基发酵液乙酸乙酯提取物的抗乙酰胆碱酯酶活性、抗菌活性和体外抗肿瘤活性进行检测,结果表明:有92.3%的提取物(浓度为100mg/mL)对AChE的抑制率...Marine-derived actinomycetes are the great component element of microbe in marine. There are innumerable kinds of marine-derived actinomycetes, which distribute widely in all kinds of marine environment. Marine-derived actinomycetes might produce different types of bioactive compounds. They are a prolific and extraordinary resource for the discovery of new drugs. This thesis covers preliminar...学位:理学硕士院系专业:生命科学学院生物学系_微生物学学号:20042602