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Study on the Isolation, Identification and Biodiversity of Myxobacteria

Abstract

天然产物是药物的重要来源。许多常用的临床药物均来自于微生物次级代谢产物。在其他已知微生物来源的新天然产物的发现量日趋减少的情况下,粘细菌由于它们结构新颖,生物活性多样而备受瞩目。然而,粘细菌还没有得到广泛的调查和利用。目前国内能够分离和纯化粘细菌的实验室屈指可数,可供培养的菌种资源还十分有限,由这一物种的生物学特性所决定难于分离和纯化进而难于筛选的特性,制约了对粘细菌天然产物的挖掘。 本论文以云南、武夷山、江西、福建等地的土样为研究材料,除了采用食草动物粪便诱导等常用方法对粘细菌子实体进行诱导、富集及分离纯化,还在此基础上对上述方法进行了改进,提高了粘细菌纯化的效率。 通过对上述样品的研究...Nature products are important source of Medicine. Many important clinical medicine are microbial secondary metabolites. Myxobacteria have a distinguished advantage in the field of producing antibiotics. Many types of novel compound with good biological activities are found from Myxobacteria. However, the Myxobacteria as a microbial resource itself has not been widely investigated and used. Curren...学位:理学硕士院系专业:生命科学学院生物学系_微生物学学号:2162007115197

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