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Relationship Between Conserved Motifs and Inhibitory Activity of Cysteine Protease Inhibitor Cystatin C of Large Yellow Croaker (Pseudosciaena crocea)

Abstract

大黄鱼(Pseudosciaenacrocea)是我国重要的海水经济养殖鱼种。随着大黄鱼养殖产业的快速发展,海水养殖过程中由细菌、病毒和寄生虫所引起的病害问题日益严重,导致了巨大的经济损失。 半胱氨酸组织蛋白酶(cysteineproteases)存在于所有生物中,在各种生理和病理过程中发挥着非常重要的作用。研究表明,半胱氨酸组织蛋白酶抑制剂(cystatin)对半胱氨酸组织蛋白酶活性的调节对生物体正常生理功能的发挥是非常重要的。cystatin是一类天然的、能与组织蛋白酶紧密结合的可逆抑制剂,广泛分布于动物组织和体液中。cystatin包含3个保守的结构域,即N-末端的Gly、第一个β-发...The large yellow croaker (Pseudosciaena crocea) is an economically important marine fish in China. With the rapid development of the large yellow croaker farming industry in recent years, infectious diseases caused by marine bacteria, viruses and parasites become more and more severe, resulting in great economic losses. Cysteine proteases exist in all living organisms and play important roles i...学位:理学硕士院系专业:生命科学学院生物学系_生物化学与分子生物学学号:2172009115205

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