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Study on the Effects and Mechanisms of Recombinant Human Prothymosin α in Metabolism of Glucose and Lipid

Abstract

目前,人们正越来越多地食用高糖高脂食品。大量临床研究表明,长期食用高糖高脂食品将引起肥胖症,而肥胖将导致机体糖耐量作用下降,引发胰岛素抵抗,最终诱发2型糖尿病。更为严重的是,糖尿病将引发如酮症酸中毒、脑血管疾病、肾病等其它并发症。如何预防和治疗糖尿病及其并发症已经成为医学界关注的焦点。糖尿病的基本特征是胰岛β细胞的结构和功能受损,导致机体胰岛素分泌不足。依赖外供给胰岛素是目前主要的治疗方案,然而通过防止胰岛β细胞凋亡和促进胰岛β细胞分裂的角度进行研究,将是预防和治疗糖尿病的新途径。 经研究证实,胸腺素α原(ProTα)具有促进机体免疫功能,促进细胞增殖和抗氧化功能的作用。由于ProTα的特殊...High sucrose and high fat diet (HSFC diet) is more and more popular in the world. There are a lot of evidence indicated that a long term intake HSFC diet will lead overweight obesis that usually will cause glucose intolerant,insulin resistance and eventually result in type 2 diabetes. Even worse, diabetes will cause ketoacidosis, cerebrovascular disease, diabetic nephropathy and other syndromes. H...学位:理学硕士院系专业:生命科学学院生物学系_动物学学号:2162007115199

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