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Preliminary study of two TRP ion channel receptors in Drosophila melanogaster immune response.

Abstract

先天性免疫是机体抵抗一切病原体的第一道防线。在过去的二十年中,黑腹果蝇(Drosophilamelanogaster)作为研究先天性免疫的一种特别有用的模型生物,从遗传学的角度详细剖析了先天性免疫的各个层面。由这些研究而来的诸多认识直接导致了哺乳动物体系的一些受体如Toll-like受体,及其信号通路的重大发现。先天性免疫在从昆虫到哺乳动物进化上的保守已经被证实。我的研究工作主要围绕黑腹果蝇的两种瞬时受体电位通道受体(TRPchannelreceptor):CG31284和CG34123。在论文里,我通过P因子介导的不精确剪切获得这两个TRP基因各自的果蝇突变体,其中,一个是CG31284基因...Innate immunity is the first line to defense host against all kinds of pathogens. In last two decades, Drosophila melanogaster has served as a particularly useful model organism for studying and genetically dissecting the aspect of innate immunity. The immense knowledge derived from such studies has led to the important discovery of the receptors like the toll like receptors and their signalling...学位:理学硕士院系专业:生命科学学院生物学系_生物化学与分子生物学学号:2172007115412

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