微生物能够产生种类繁多、结构新颖、活性多样的次级代谢产物，是发现先导化合物的重要来源，随着陆地可培养微生物资源的开发，从中发现新菌种、新代谢产物的可能性日趋减小，人们将目光投向了海洋等等新资源来筛选高活性的微生物菌种，从而提高发现先导化合物的效率。 本文以耻垢分支杆菌(Mycobacteriumsmegmatis)为指示菌，对福建省药物工程实验室保藏的539株小单孢菌菌科(Micromonosporaceae)的菌株进行了抗结核活性的筛选，初筛得到了58株阳性菌株，阳性率为10.76%，阳性菌株中鉴定到属的菌株包括：小单孢菌属、疣孢菌属、盐生孢菌属。活性复筛的阳性率74.14%，小单孢菌株用...Microorganisms are capable of generating a wide range of secondary metabolites with novel skeletons and varied and unique bioactivities which are important resources of lead compounds discovery. As the terrestrial sources have been fully researched, the possibility of discovering novel species and secondary metabolites has been sharply declined. In order to obtain new drugs people pay more attenti...学位：理学硕士院系专业：生命科学学院生物化学与生物技术系_微生物学学号：2172009115213
