Ibuprofen and Myristic Acid Microparticles and Microcomposites Generated by a PGSS Process

Abstract

超临界流体微粒化技术是当前化学工程、材料科学、医药工程等领域的重要研究方向,而超临界流体制备微胶囊技术更是近年来国内外积极研发的一项新技术。获得粒径小、分布均匀且能控制药物释放速率的药物微胶囊是人们追求的目标。与传统方法相比,超临界流体微粒化/微胶囊技术具有产品纯度高、粒径分布可控、制造工艺简单、操作温度低、避免或少用有机溶剂等许多明显的优点。气体饱和溶液微粒形成技术(ParticlesFromationfromGas-SaturatedSolutions,PGSS)是近年来提出的一种新型的超临界流体微粒化及微胶囊化新技术。本文涉及的研究内容包括两方面:气液固三相平衡的基础研究和PGSS技术的...Using supercritical fluids (SCFs) to manufacture microparticles/microspheres is a promising direction in chemical engineering, material science, pharmaceutical, and so on. SCF technology has some significant advantages over traditional methods, such as little environmental pollution, preferable particle morphology (PM), controllable particle sizes, and simple equipments. In order to obtain desired...学位:工学硕士院系专业:化学化工学院化学工程与生物工程系_化学工程学号:20043301

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