Joint Toxicological Effects and Proteomics in Zebrafish Brain under the Combination Stress of Methyl Parathion with Cadmium

Abstract

对多种污染物产生联合毒性效应的研究已成为环境科学发展的重要方向之一。目前,有关污染物的生物效应研究多数还是集中在单个化合物,因而有关预测和治理多种毒物对生物产生联合毒性的研究,越来越受到环境科学家的关注和重视,特别是有关有机磷农药和重金属的联合毒性效应研究。本文选取了在水体污染中比较有代表性的甲基对硫磷(MP)和重金属镉(Cd)为共污染物,以经典的模式生物斑马鱼(Daniorerio)为实验材料,从生理生化指标的变化、蛋白的差异表达等几方面对MP和Cd对斑马鱼脑组织的联合胁迫效应进行了较为系统的研究。 首先,对MP和Cd分别胁迫斑马鱼后产生的急性毒性效应进行分析。结果显示MP对斑马鱼的半致死...Combined pollution has become one of the important directions of research in environment science at present. Before now most of the research has concentrated on the action of single compound against organisms. Due to the presence of multiple pollutants in natural environments, environmental scientists are paying more attentions on the joint toxicological effects, especially about the combination o...学位:理学博士院系专业:化学化工学院化学系_化学生物学专业学号:1912005140309

    Similar works