摘要 癌症是威胁人类健康的重大疾病之一，恶性肿瘤的治疗在很大程度上仍以化疗为主。近年来，载药微泡联合超声辐照治疗肿瘤也日益受到重视。 羟基喜树碱（HCPT）是一种广谱的抗肿瘤药物，临床上主要剂型为注射用冻干粉。聚乳酸（PLA）有良好的生物相容性和生物降解性，在生物医学领域有广泛的应用前景。为了增加靶向部位血药浓度，降低给药量，减小毒副作用，本课题探索载羟基喜树碱－聚乳酸微泡的制备及超声辐照下对肿瘤细胞生物效应的影响。 本文的主要研究包括： (1)以聚乳酸为成膜材料，对可能影响空白微泡形貌的各个参数进行单因素考察，优化出最佳微泡设计方案； (2)以羟基喜树碱为模型药物，制备载羟基喜树碱...Abstract Cancer is one of chief diseases to threat the health of human being. Chemical therapy is an important method to treat it comparing with operation and radial therapy. Recently there are more and more researches about microbubbles especially which load with drugs and people are focus on the potential of the high therapy of microbubbles exposed to ultrasound. Hydroxycamptothecin (HCPT) is ...学位：理学硕士院系专业：材料学院生物材料系_生物医学工程学号：2452007115258
