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Role of Chemokines CXCL9 and CXCL10 in Acute Transplant Rejection Mediated by Alloreactive Memory T Cells in a Mouse Cardiac Retransplantation Model

Abstract

目的 在机体抵抗感染等外来致病原入侵的这些环节上,记忆性T淋巴细胞起着相当关键的作用,但越来越多的研究证明,在器官移植中记忆性T淋巴细胞所起的作用却是非常不利的。由于有记忆性T淋巴细胞的存在,再次器官移植急性排斥反应的发生、发展速度都远快于初次器官移植。本研究主要探讨趋化性细胞因子CXCL9和CXCL10在记忆性T淋巴细胞介导的小鼠再次心脏移植急性排斥反应中表达的变化及意义。 方法 Balb/c小鼠作为供鼠,C57BL/6小鼠作为为受鼠,进行背部皮肤移植。分为四组进行实验:实验组,C57BL/6小鼠进行皮肤移植饲养6周后,以Balb/c小鼠为供鼠,采用套管法进行颈部异位心脏移植;对照组,...Objective: Although memory T cells are always useful for resisting infection by pathogens, it is indeed a barrier to achieving the long-term allograft survival and transplant tolerance. Due to donor-reactive T cells, rejection of most second transplantations of organs is more intense than the first transplantation. Here, we investigated the effect of the chemokines CXCL9 and CXCL10 in a mouse re...学位:医学硕士院系专业:医学院_外科学学号:2452011115342

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