背景：组蛋白去乙酰化酶抑制剂（histonedeacetylaseinhibitor，HDACI）作为一类新型抗肿瘤药物已被大家熟知，然而，随着研究的深入，人们发现其还能被用于治疗多种非肿瘤性疾病，如炎症、自身免疫性疾病、器官移植排斥等。SAHA（suberoylanilidehydroxamicacid）是目前研究得最多、最深入的一种HDACIs，它能够有效抑制Ⅰ型和Ⅱ型HDACS、促使乙酰化组蛋白增加、导致肿瘤细胞的转录过程出现异常，进而诱导肿瘤细胞周期停滞、分化乃至凋亡。目前，人们对于SAHA的研究多局限于其抗肿瘤领域，而对其在免疫调节方面尤其是移植免疫领域的调节作用还了解甚少。探讨SA...Background Histone deacetylase inhibitors (HDACIs) are a new class of anticancer drugs, but people are more concerned about the anti-tumor effect of ignoring the role of other fields. In fact, with the development of research, people find it also has great prospects in the treatment of inflammatory,autoimmune disease and transplant related diseases . SAHA(suberoylanilide hydroxamic acid) is one o...学位：医学硕士院系专业：医学院_内科学学号：2452011115332
