InCl3 Catalyzed One-Pot Synthesis of Highly Substituted Pyrroles from Propargylic Alcohols, 1,3-Dicarbonyl Compounds and Primary Amines and Synthesis of 2'-Deoxy-β-L-thymidine and C24H30 as Precursor to C24, C24H12 Fullerene

Abstract

一、InCl3催化的炔丙醇、1，3-二羰基化合物和伯胺一锅法合成多取代吡咯 吡咯广泛存在于各种天然产物和各种生物活性物质中，并已应用于制药领域的合成。即使在非天然的有机小分子中，吡咯也作为一个重要的结构单元出现在各种有机合成的中间体之中。因此，吡咯环的合成一直是有机化学家感兴趣的课题。我们成功发展了一种快速有效的三氯化铟催化的炔丙醇、1，3-二羰基化合物和伯胺一锅法合成多取代吡咯的新方法。该方法经连续的取代/胺化/成环过程，中间体无需分离，一锅法即可得到五取代吡咯环产物。反应条件温和，适用于多种类型取代基的吡咯环合成，反应所用金属催化剂便宜易得，对环境友好，可作为多种吡咯合成方法的又一重要补...1. InCl3 Catalyzed One-Pot Synthesis of Highly Substituted Pyrroles from Propargylic Alcohols, 1,3-Dicarbonyl Compounds and Primary Amines Pyrrole was widely found in various natural products and many bioactive materials, and had been applied to the synthesis of the pharmaceutical area. Pyrrole, as an important structure unit, was shown in many organic synthesis intermediates even in non-natura...学位：理学硕士院系专业：化学化工学院化学系_有机化学学号：2052006115193