Cloning, expression and characterization of membrane lipid rafts related gene SpFLT-1 and its functional study during pathogens endocytosis in Scylla paramamosain
拟穴青蟹(Scyllaparamamosain)是我国最重要的海水养殖蟹类之一，具有重要的营养价值和经济价值。集约化的养殖模式导致了近年来拟穴青蟹的疾病不断爆发，其中以弧菌等革兰氏阴性菌为主的细菌性病原是导致青蟹发病的重要诱因之一。然而由于对病原微生物感染拟穴青蟹的致病机理知之甚少，目前对其尚无有效的免疫防治措施。因此，阐明病原微生物的致病途径对于控制拟穴青蟹疾病爆发具有重要的意义。 病原微生物在长期的进化过程中发展出一整套逃避、干扰、抑制和对抗宿主免疫系统的机制，其中利用宿主的细胞膜结构和受体蛋白进入胞内是病原微生物感染宿主的重要途径之一。为了研究病原在入侵拟穴青蟹过程中与宿主作用的关键蛋...The mud crab, Scylla paramamosain is one of the most important marine breeding crabs in China, with vital nutritional and economic value. The animals are usually raised in ponds at high densities which has led to disease epidemics in recent years. Bacteria especially Gram-negative bacteria (e.g. Vibrios), are one of the leading pathogens infecting these crabs. However, the pathogenesis is poorly u...学位：理学博士院系专业：环境与生态学院_环境科学学号：2262009015327
