Study of self-aggregated nanoparticles of N-stearic acid-O-carboxylmethyl chitosan derivatives and the primary application as the novel carriers of drugs
两亲性聚合物在水性介质中能通过自组装方式形成纳米胶束，该类胶束具有独特的核-壳结构及体内长循环和主体稳定等特点；且由于具有增强渗透滞留效应（EnhancedPermeabilityandRetentionEffect，EPR），该类聚合物胶束能在肿瘤病变部位富集，实现对肿瘤组织的“被动靶向”作用，将其作为抗肿瘤药物载体，是提高药物疗效，降低药物毒副作用的有效策略之一。O-羧甲基壳聚糖（O-carboxylmethylchitosan，CMC）是一种水溶性壳聚糖衍生物，保留了壳聚糖生物相容性好、可生物降解、无免疫原性、无毒性等独特优点，将其疏水改性后形成两亲性壳聚糖，具有两亲性质，在一定条件下能...Amphiphilic conjugate have received increasing attention because they can form self-aggregated nanoparticles. In the aqueous phase, the hydrophobic cores of polymer ric nanoparticles are surrounded by hydrophilic outer shells. Thus, the inner core can serve as a nano-container for hydrophobic drugs. The nanoparticles can accumulate and extravasate within tumor tissue due to the prolonged circulati...学位：理学博士院系专业：化学化工学院_高分子化学与物理学号：2072006015328
