Clinical significance in diagnosis and chemotherapy monitoring in patients with gastrointestinal cancer with tests for serum and urine levels of trefoil factor 3
背景和目的：TFF3作为一种分泌蛋白，既往多个研究报道其可以作为多种恶性肿瘤的血清标志物。我们通过检测胃肠道患者血清及尿液TFF3水平，研究血清和尿液TFF3能否成为胃肠道肿瘤的标志物，研究其能否成为化疗疗效的预测指标。 方法：我们收集来自厦门大学附属中山医院肿瘤内科经过病理确诊的90名胃癌患者和128名结直肠癌患者的血液和尿液样本。所有病例均符合入组标准。收集来自厦门大学附属中山医院体检中心91名无癌健康志愿者的血液和尿液样本作为对照组。血清及尿液TFF3水平使用酶联免疫吸附法检测。对比分析不同组的血清和尿液TFF3水平与临床病理参数之间的关系。比较不同组化疗前后血清和尿液TFF3水平的变...BACKGROUND & AIMS: As a secreted protein, serum TFF3 has been reported to be a biomarker for several malignancies. We further investigated whether TFF3 can be applied as a biomarker for and predictor of responses to chemotherapy in gastrointestinal cancer. METHODS: Serum and urine samples were collected from 90 patients with gastric cancer, 128 patients with colorectal cancer and 91 healthy indiv...学位：医学硕士院系专业：医学院_内科学学号：2452011115338
