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Study on Solid-State Polycondensation and Properties of Poly(Lactic Acid-co-Glycolic Acid)

Abstract

聚乳酸乙醇酸(PLGA)是一类重要的生物可降解材料。PLGA的制备方法主要有开环聚合法和直接熔融缩聚法两种。但是,开环聚合法条件苛刻,且所用的锡类催化剂具有细胞毒性。因此,使用低毒催化剂或在无催化剂条件下,直接熔融聚合制备生物医学工程材料要求的PLGA是目前研究的热点。 本文以乳酸(LA)、乙醇酸(GA)为原料,在无催化剂的条件下熔融聚合合成聚乳酸乙醇酸(PLGA)低聚物,采用红外、核磁共振、XRD、DSC、特性黏数等对产物进行表征,探讨聚合条件、单体投料比对聚合物分子量和结晶性能的影响。结果表明,在150℃下,反应20h后,PLGA的粘均分子量为2.82×104;在160℃下继续反应36...Poly (lactic acid-co-glycolic acid) (PLGA) is one of the most important biodegradable polyester materials. PLGA is mainly synthesized through two ways, ring-opening polymerization and direct melt polymerization. But the application of ring-opening polymerization is limited due to harsh conditions and the use of tin catalysts which show cell toxicity. Therefore, it is a hotspot that research on syn...学位:工学硕士院系专业:材料学院_材料物理与化学学号:2072010115007

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