The change of microprocessor to "multi-core" is not only a new start of the healthy progress of the processor technology, but also a milestone of the development history of computer technology. Naturally, curriculums which are closely related to the hardware will be adjusted with the appearance of "multi-core". In this paper, we introduced the practice and experience of curriculums design based on multi-core platform in the postgraduate and senior undergraduate course-"Real-time system analyses and design"