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不同HBsAg疫苗联合免疫后诱导小鼠细胞和体液免疫应答的研究
Authors
伍小路
吴婷
+5 more
夏宁邵
张军
欧山海
陈敏
颜渊清
Publication date
18 September 2006
Publisher
Abstract
目的:了解HBsAg的蛋白疫苗(P)、痘苗病毒疫苗(V)、DNA疫苗(D)联合免疫小鼠诱导的特异性体液和细胞免疫应答。方法:以P、V或D疫苗中的一种疫苗初次免疫BALB/c小鼠后,于第2、5、8、11周再用另一种疫苗加强,共产生9种免疫组合:即PP、PV、PD、VP、VV、VD、DP、DV及DD。于初免后第2、5、8、11周采血检测血清中抗HBsAgIgG的总滴度及其IgG1和IgG2a亚类,并于每次加强免疫后第7天,检测小鼠脾脏的CTL对P815S细胞的特异性杀伤率。结果:在P、V、D3种疫苗中,V疫苗诱导产生抗HBsAg抗体的速度最快,P疫苗诱导的体液免疫回忆反应最强,D疫苗诱导产生的抗体最弱。除PP疫苗组合诱导的抗体明显倾向于IgG1外,其他均无明显的倾向性。各种免疫组合中,VD和DV疫苗组诱导的CTL应答最强,对P815S的特异性杀伤率分别为71%和64%。结论:在各种联合免疫组合中,PV、PD、VP和VD疫苗组的抗体应答较好;而DV和VD疫苗组诱导的CTL杀伤效应最强
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Last time updated on 16/06/2016