通讯作者。Tel: 0592-2189390, E-mail: [email protected][中文文摘]丝裂原活化蛋白激酶家族可以在一系列细胞外刺激下调控细胞的行为。作为该家族的四个亚家族之一,p38亚族在许多生理过程中扮演着重要角色。p38信号通路可以在紫外照射、热击、高渗透压、炎症因子、生长因子等细胞外刺激时被激活,调控细胞分化、细胞周期、炎症反应等多种生理过程。文章重点讨论了p38亚族各个成员的特性、该信号通路的组成部分、调控机制以及生物学功能。另外,还分析了p38与其他信号通路的联系以及对一些生理过程的影响。[英文文摘]The members of the mitogen-activated protein kinase family participate in cellular responses to a wide range of extracellular stimuli. One of the four sub-families, the p38 group MAP kinases, plays a vital role in numerous biological processes. The p38 signaling pathway can be activated in response to many physical, chemical,and biological stresses, including UV light, heat shock, osmotic shock, inflammatory cytokines, and growth factors.The p38 pathway also regulates various physiological processes such as cell differentiation, the cell cycle, and inflammation. This review focuses on the characteristics of each p38 member, the components of the p38 pathway, and the mechanisms and consequences of p38 activation. We also discuss the interplay between the p38 pathway and other signaling pathways
