【中文摘要】 细胞溶质内的游离钙离子在许多细胞活动中发挥着重要的作用。对于神经元,细胞膜上的神经电信号和胞内钙离子化学信号之间有着复杂的相互作用,每个神经元都可看作为一个含有细胞膜和内质网膜的双膜系统,而神经细胞的内质网则可视为神经元内的神经元。本综述探讨了神经元膜上神经电信号与内质网钙通道释放的胞内钙信号相耦合的动力学模型。我们认为,计算神经动力学的一个研究方向是考虑包含胞内钙动力学的神经元模拟,而且该研究前沿转向考虑胞内钙波扩散运动的空间神经元模型。包含内质网钙动力学的神经模型,尤其是考虑胞体和树突内钙扩散的空间神经元模型,将加深我们对神经动力学的认识。
【英文摘要】 Cytosolic Ca2+ ions play an important role in the regulation of numerous aspects of cellular activity in virtually all cell types. There is a complex interaction between the neuronal electrical signals on plasma membrane and the chemical signals of intracellular calcium. Each neuron can be considered as a binary membrane system with plasma membrane and endoplasmic reticulum membrane, and the neuronal endoplasmic reticulum can be regarded as a neuron-within-a-neuron. This review explores the simulation model...supported by the National Natural Science Foundation of China (No. 30970970
