作者简介: 江宇良( 1985) , 男(汉族) , 江西樟树人, 现为厦门大学生物化
工专业在读硕士研究生, 主要从事生物材料研究工作.[中文文摘]目的应用天然药用高分子材料海藻酸钠和淀粉制备复合微球并研究其对盐酸小檗碱的控制释放性能。方法采用改进的乳化凝胶法制备复合微球,用光学显微镜观察了微球的形态,共聚焦激光扫描显微镜观察了药物的分布情况,紫外分光光度计测定了药物包封率,并测定了药物在不同介质中的释放。结果微球形态圆整,分散性好,包封率可达到80%以上,对盐酸小檗碱具有一定的缓控释效果。结论以海藻酸钠和淀粉为原料制备了性能良好的复合微球。
[英文文摘]Objective To prepare blend microspheres natural polymers alginate and starch and to study their controlled release performance on berberine hydrochloride.Methods A modified emulsification/gelation method was applied to prepare blend microspheres.Shape of those microspheres was observed with optical microscope.Drug distribution inside the Microspheres was observed with CLSM.Encapsulation efficiency was determined by UV-spectrophotometer.Drug release performance in two medium was also tested.Results Microspheres appeared to be spher ica l and w ell d ispersed in w ater. Encapsu lation effic iency was higher
than 80%. M icrospheres was found to have a certa in effect on the contro lled release of berber ine hydroch lo ride. Conclusion
B lend m icrospheres w ith good perfo rmancew ere prepa red w ith a lg ina te and starch国家自然科学基金(No.50573063)，教育部新世纪优秀人才计划项目(No.NCET-05-0566)，高等学校博士点专项基金(No.2005038401
