A collection of studies into the pathogenesis of preeclampsia (PE) and intrauterine fetal growth restriction (IUGR) are presented, focusing on factors involved in the angiogenesis as well as maternal factors such as circulating monocytes and lipid status. Placental expression of PlGF and KDR were significantly reduced in IUGR Adescription of digital image analysis techniques in the assessment of angiogenic factor expression in the placenta is presented. The study on circulating angiogenic factors showed elevated sFlt-1 and sEndoglin and low PlGF in preeclampsia and IUGR. Pro and anti-angiogenic factors and their ratios were assessed as biomarkers for pathological pregnancies. Maternal and fetal monocyte phenotype and polarization were examined inPE and IUGR. Ahigher percentage of intermediate and non-classical monocytes were found in PE and IUGR. Evaluation of inflammatory and healing monocyte phenotypes showed a shift towards healing phenotype in IUGR. The maternal and fetal triglyceride levels were higher in preeclampsia. This study documented the first description of elevated Apo lipoprotein B levels in cord blood at delivery in PE and IUGR. This research contributes to the literature on pathogenesis of preeclampsia and intrauterine growth restriction, demonstrating similarities and differences between the conditions which has lead us closer towards understanding their pathogenesis
