In spite of current interpretations, this essay investigates the intimate link between cosmology and anthropology in Kant’s thought. Drawing the most incisive consequences both of the copernican revolution and Colombo’s discovery, Kant’s cosmological anthropology reveals to be the modern uneasy mundana sapientia, and let us thoroughly understand the pregnant meaning of the historiographic topos “man and world”. World – not God, Being or Truth, and even not Reality – assert itself as the most important reference point to comprehend human condition, although the world-concept became far more problematic than in the past In cosmological perspective world is neither exclusively nature nor exclusively ideal guidance, but pragmatic-cosmopolitan world, i.e. a pervasive “in-between position”, which causes a constitutive imbalance we have permanent to cop with. So is open the way leading to contemporary philosophical anthropology